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TitlemiRTarBase 2020: updates to the experimentally validated microRNA-target interaction database
Author (Name in English or Pinyin)
Huang, H.-Y.1,2; Lin, Y.-C.-D.1,2; Li, J.1,2; Huang, K.-Y.1,2; Shrestha, S.3; Hong, H.-C.1,2; Tang, Y.1,2; Chen, Y.-G.1; Jin, C.-N.1; Yu, Y.4; Xu, J.-T.1; Li, Y.-M.4; Cai, X.-X.1; Zhou, Z.-Y.1; Chen, X.-H.5; Pei, Y.-Y.5; Hu, L.5; Su, J.-J.5,6; Cui, S.-D.1; Wang, F.1,2; Xie, Y.-Y.1; Ding, S.-Y.1; Luo, M.-F.1; Chou, C.-H.3,7; Chang, N.-W.8; Chen, K.-W.9; Cheng, Y.-H.3; Wan, X.-H.5; Hsu, W.-L.10; Lee, T.-Y.1,2; Wei, F.-X.5,6,11; Huang, H.-D.1,2,3
Date Issued2020-01-08
Source PublicationNucleic acids research
ISSN1362-4962
EISSN1362-4962
Volume48Issue:D1Pages:D148-D154
AbstractMicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18-25 nucleotides) that negatively control expression of target genes at the post-transcriptional level. Owing to the biological significance of miRNAs, miRTarBase was developed to provide comprehensive information on experimentally validated miRNA-target interactions (MTIs). To date, the database has accumulated >13,404 validated MTIs from 11,021 articles from manual curations. In this update, a text-mining system was incorporated to enhance the recognition of MTI-related articles by adopting a scoring system. In addition, a variety of biological databases were integrated to provide information on the regulatory network of miRNAs and its expression in blood. Not only targets of miRNAs but also regulators of miRNAs are provided to users for investigating the up- and downstream regulations of miRNAs. Moreover, the number of MTIs with high-throughput experimental evidence increased remarkably (validated by CLIP-seq technology). In conclusion, these improvements promote the miRTarBase as one of the most comprehensively annotated and experimentally validated miRNA-target interaction databases.
DOI10.1093/nar/gkz896
Indexed BySCIE
language英语
Funding ProjectGanghong Young ScholarDevelopment Fund of ShenzhenGanghong Group Co., Ltd. 'Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B)' from The Featured Areas Research Center Program
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000525956700022
PublisherOXFORD UNIV PRESS
Original Document TypeArticle
Firstlevel Discipline生物学
Education discipline科技类
Published range国外学术期刊
Volume Issue Pages卷: 48 期: D1 页: D148-D154
References
[1] Bartel, D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-297.
Data SourceWOS
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Identifierhttps://irepository.cuhk.edu.cn/handle/3EPUXD0A/1008
CollectionSchool of Medicine
Arieh Warshel Institute for Computational Biology
Institute of Urban Underground Space and Energy Studies
Co-First AuthorLin, Y.-C.-D.
Corresponding AuthorLee, T.-Y.; Wei, F.-X.; Huang, H.-D.
Affiliation
1.School of Life and Health Sciences, Chinese University of Hong Kong, Guangdong Province 518172, Longgang District, Shenzhen, China
2.Warshel Institute for Computational Biology, Chinese University of Hong Kong, Guangdong Province 518172, Longgang District, Shenzhen, China
3.Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan
4.School of Science and Engineering, Chinese University of Hong Kong, Guangdong Province 518172, Longgang District, Shenzhen, China
5.Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Guangdong Province 518172, Shenzhen, China
6.Department of Cell Biology, Jiamusi University, Heilongjiang Province 154007, Jiamusi, China
7.Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Chiao Tung University, Hsinchu, Taiwan
8.Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan
9.Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan
10.Institute of Information Science, Academia Sinica, Taipei 115, Taiwan
11.Department of Pathogenic Microorganisms, Zunyi Medical University, Guizhong Province 563006, Zunyi, China
First Author AffilicationSchool of Medicine
Corresponding Author AffilicationSchool of Medicine
Recommended Citation
GB/T 7714
Huang, H.-Y.,Lin, Y.-C.-D.,Li, J.et al. miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database[J]. Nucleic acids research,2020,48(D1):D148-D154.
APA Huang, H.-Y., Lin, Y.-C.-D., Li, J., Huang, K.-Y., Shrestha, S., .. & Huang, H.-D. (2020). miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database. Nucleic acids research, 48(D1), D148-D154.
MLA Huang, H.-Y.,et al."miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database".Nucleic acids research 48.D1(2020):D148-D154.
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miRTarBase 2020 upda(3181KB)Journal article--Published draftRestricted AccessCC BY-NC-SA
gkz896_supplemental_(384KB)Other-- Restricted AccessCC BY-NC-SA
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